SkinMedica Retinol Complex 0.5 dupe

Neutrogena Rapid Wrinkle Repair Retinol Pro+ Power Serum

−63%per oz

SkinMedica · $80Neutrogena · $29.97

Shared: Retinol
The trade-off: SkinMedica puts it in a water-based cream-serum with niacinamide, a peptide, soybean oil and squalane, while Neutrogena's is a water-free, silky oil-serum with fragrance, so sensitive skin may do better with the SkinMedica.
Sizes: 30 ml against 30 ml

Retinol Complex 0.5 costs about $80 for 30 ml ($78.86 / fl oz). The dupe below is Neutrogena Rapid Wrinkle Repair Retinol Pro+ Power Serum at $29.97, about 63% less per ounce. Each pair is compared on format, finish and key ingredients, including what the dupe doesn't do.

Night serum with 0.5% retinol, niacinamide and a calming peptide in a soybean oil and squalane base, with bisabolol and vitamin E. For skin already used to retinol.

Amazon prices as of Sep 28, 2026, 1:12 AM ET, subject to change: the price on Amazon at checkout is the one that applies.

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The dupe, side by side

The original

SkinMedica

Retinol Complex 0.5

$80

$78.86 / fl oz

Cost per fl oz

SkinMedica$78.86 / fl oz

Neutrogena$29.54 / fl oz

$50.03 less at checkout than the original.

Size: Original · SkinMedica30 ml; Dupe · Neutrogena30 ml
Key ingredients: Original · SkinMedicaRetinol, Niacinamide, Palmitoyl tripeptide-8; Dupe · NeutrogenaRetinol, Bisabolol

What matches

Same active: pure retinol, 0.5% in SkinMedica and Neutrogena's highest concentration in the Pro+, both with bisabolol and vitamin E to take the edge off irritation.

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Questions

What is the best dupe for SkinMedica Retinol Complex 0.5?

Neutrogena Rapid Wrinkle Repair Retinol Pro+ Power Serum at about $29.97. Same active: pure retinol, 0.5% in SkinMedica and Neutrogena's highest concentration in the Pro+, both with bisabolol and vitamin E to take the edge off irritation.

How much cheaper is Neutrogena Rapid Wrinkle Repair Retinol Pro+ Power Serum than Retinol Complex 0.5?

Retinol Complex 0.5 costs about $80 for 30 ml, or $78.86 / fl oz. Neutrogena Rapid Wrinkle Repair Retinol Pro+ Power Serum works out at $29.54 / fl oz, roughly 63% less per ounce.

What does Neutrogena Rapid Wrinkle Repair Retinol Pro+ Power Serum do worse than Retinol Complex 0.5?

SkinMedica puts it in a water-based cream-serum with niacinamide, a peptide, soybean oil and squalane, while Neutrogena's is a water-free, silky oil-serum with fragrance, so sensitive skin may do better with the SkinMedica.